So an overview, Nicodem is a very defensive master who although is best near to your crew for support shouldn't be too near to the front because with a meagre defense of 3 and no defensive triggers or tricks to get him out of melee he just dies fast. Activation wise I find Activating the big man first is a good plan as it allows you to get up the bolster aura straight away and with The Fog he will be pretty safe as long as he isn't out in the open on his own. I will always take Nicodem with a Cache of 6+ as any less means he can struggle to summon or get off Rigor Mortis when he really needs to. They are also useful for if he does come under attack giving him a little defence.